|Minimum Order Quantity||100 Vial|
|Store at||2 to 8 Degree C|
|Minimum Order Quantity||300 Vial|
|Product Type||Finished Product|
Snake Venom Antiserum (African) is a sterile preparation contains equine immunoglobulin fragments F(ab’)2. Freeze dried powder is reconstituted in 10 ml of sterile water for Injection supplied along with the vial. Each ml has power of specifically neutralizing the venoms of following species of snakes.
The antitoxic equine Immunoglobulins and their derivatives are obtained from the serum of healthy equines immunized against venoms of above species of snakes.
Reconstitution of Lyophilised Serum
The antiserum is supplied in liquid as well as in freeze dried form. The freeze dried powder is reconstituted with 10 ml of sterile water for injection supplied with this pack. The whole content of freeze dried powder dissolves into a clear colorless or pale yellow liquid.
Each mL upon reconstitution to 10 mL with Sterilised Water for Injections B.P. neutralises the snake
venoms of the following :
Naja nigricollis Cerastes
Preservative: Cresol B.P. <0.25% v/v
Cobra Antivenin is a sterile preparation containing equine immunoglobulin fragments F(ab’)2. Freeze dried powder when reconstituted to 10mL of Sterilized Water for Injections B.P. supplied along with the vial, each 1mL has capacity of specically neutralizing the venom of the following species of Snake.
Naja kaouthia – 0.600 mg
The antitoxic equine immunoglobulin and their derivatives are obtained from the serum of healthy equines hyperimmunized against Monocle Cobra venom.
Each 1 ml serum contains antibodies that neutralize the following venoms :
Leiurus quinquestraitus 50LD50
Androctonus ameoreuxi 35LD50
Ortho-Cresol (preservative) 0.25%
Venom from a single scorpion may contain several neurotoxins such as histamine, serotonin and enzymes. The most important clinical effects of envenomation are neuromuscular, neuroautonomic or local tissue effects.
Grades of Clinical Picture Serverity:
Grade 0 : No Local or Systemic Signs.
Grade I : Local Signs, pain, and / or parathesia at the site of string.
Grade II: Local Signs and pain + remote pain and / or parathesia.
Grade III: Local pain + cranical, autonomic or somatic neuromuscular dysfunction.
Treatment of envenomation from the stings of the scorpion species mentioned in composition.
The product is given by intramuscular, subcutaneous or intravenous injection. The dose is not related to the age or body weight. A skin test must be done before giving anti-scorpion venom serum (see under precautions)
In grades I, II and III, the dose may be repeated after 1-2 hours if improvement has not occurred. The dose should be increased if the interval between the sting and the treatment is prolonged or the site of the sting is on the head, neck or shoulders. Place ice on the sting site and immobilize the stung limb to reduce pain and venom extension.
Reconstitution of the Lyophilized Antiserum:
Remove the flip off on the seal over the diaphragms of the vials of antivenin and diluents. Sterilize the rubber diaphragm with alcohol. Withdraw the diluent in a sterile syringe. Insert the needle through the stopper of the vial containing antiserum and point the diluent jet to the center of lyophilized pellet to be dissolved and in order to prevent floating. Swirl the vial gently for one to five minutes and do not shake to avoid foaming.
Rabies Antiserum I.P. (5 ml Vial)
Each ml of Rabies Anti Serum contains not less than 300 I.U.
NMT 0.25% w/v
etanus Antitoxin I.P. Therapeutic (5 ml Vial)
NMT 0.25% w/v
Polyvalent Snake Venom Antiserum (Central Africa) is prepared from hyper-immunised equines against the venoms of the corresponding venomous snakes, namely:
Plasma obtained from the hyper-immunized equines is enzyme refined, purified and concentrated. Each mL of the Snake Venom Antiserum (after reconstitution to 10 mL for lyophilised form) neutralizes not less than the following quantities of venoms when tested in mice:
Snake envenomation is serious and could be life threatening.
The consequences of the action of snake venoms vary considerably based on the group to which the particular venom belongs. This, in turn depends upon the composition of the venom. In envenomation by viperid and crotalid snakes, venom (Cytotoxic) breaks down tissues destroying the red blood cells, e.g. Gaboon viper, Russell’s viper and Saw scaled viper.
In cases of viper envenomation (Gaboon viper, Russell’s viper and Saw scaled viper) the venom is characterized by a low content of neurotoxins, but large quantities of cytotoxins and these being proteins of high molecular weight, diffuse slowly within the tissues, hence they initially cause severe symptoms of poisoning in the region of the bite. Consequently, local symptoms are prominent and severe. There is great and persistent pain and intensive swelling at the bite site. The venom of the viper contains several enzymes which may possibly act synergistically to produce shock, spontaneous hemorrhages in the organs and tissues, acute necrosis and death. There is constant and incessant oozing of blood from the bite site. Sloughing too occurs permitting other infections.
(10 mL-Liquid/Lyophilised, Polyvalent,Enzyme Rened, Equine immunoglobulins)
Snake Venom Antiserum Echis is a sterile preparation containing equine immunoglobulin fragments F (ab’) 2. Freeze dried powder when reconstituted with 10mL of Sterilised Water for Injections B.P. supplied along with the vial.
Each lmL has capacity of specically neutralizing 40 LD50 of Echis ocellatus venom.
The antitoxic equine immunoglobulin and their derivatives are obtained from the serum of healthy equines immunized against venom of the above species of snake.